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Prior research into the mechanisms that regulate muscle mass in adults have highlighted the importance of the ActRIIA/B receptor systems, as blocking these receptors can result in profound muscle growth in adult animals and humans 19,21,22

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A poorly designed protocol can lead to receptor downregulation, conflicting signals, or simply wasted resources

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But even adjusting for duration, the Phase 3 results confirm that retatrutide maintains its weight loss trajectory well beyond the initial treatment period