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Due to the inconsistency and publication bias, the quality of evidence on absolute and percentage of weight loss, weight loss targets of at least 5% and 10% were degraded to moderate level

This typically involves providing evidence of obesity-related health issues, such as diabetes, hypertension, or sleep apnea, and demonstrating that non-surgical interventions have been unsuccessful

doi: 10.1186/1471-2377-11-62 67 BuchwaldDHerrellRAshtonSBelcourtMSchmalingKSullivanPet al

Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M, Zhu S, Cao Z, Liang Y, Sboner A, Tap WD, Fletcher JA, Huberman KH, Qin LX, Viale A, Singer S, Zheng D, Berger MF, Chen Y, Antonescu CR, Chi P (2014) PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

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