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In turn, the SCN synchronizes subsidiary circadian oscillators present in virtually every peripheral tissue (heart, liver, kidney, lungs, immune cells, etc.) coordinating their rhythms via neural and hormonal signals

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For example, brain derived neurotrophic factor (BDNF) and TNF protect neurons against excitotoxicity through activation of the transcription factor NF-kB, which induces the expression of antioxidant enzymes such as Mn-SOD and the anti-apoptotic proteins, Bcl-2 and inhibitor of apoptosis proteins IAPs [123,124]

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This allows it to bypass harsh digestive conditions and slip through the gut wall more efficiently, landing directly in your bloodstream