Regarding dose distribution, differences exist between Gamma Knife and Linac-SRT: the former typically prescribes the dose to the 50% isodose line (e.g., 15Gy delivered to the 50% isodose line results in a maximum intratumoral dose of 30Gy), and due to its focused irradiation characteristics, the target dose distribution is relatively inhomogeneous
At the same time, a few states expanded access (Missouri, Tennessee, and Utah), reflecting competing pressures between clinical demand and budgets
OCallaghan, P., Meleady, R., Fitzgerald, T., Graham, I., & European COMAC group (2002)
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Some state pharmacy boards have tightened oversight in 2025-2026