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Frequency has a significant impact on overall cost

In silico analysis from publicly available murine model datasets that may be associated with BBR demonstrated pathways including Nuclear Factor kappa B (NF-B), IL-17, TNF, and inflammatory response [56]

May support slow-wave and REM sleep architecture, per a placebo-controlled polysomnography study in younger and older adults (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)