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Additionally, impaired mitochondria disrupt cellular processes such as apoptosis and autophagy, further contributing to neuronal loss and pathology in these diseases (Muddapu et al., 2020)

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doi: 10.1124/pr.115.011395 8 DruckerDJ

Nrf2 controls the expression of several enzymatic antioxidants and results in the modulation of the levels of ROS, such as SOD, CAT, GPx, and heme oxygenase-1 (HO-1), which are vital in maintaining redox balance and cellular homeostasis