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During the MASLD-induced mitochondrial dysfunction, the microsomal CYP2E1- and CYP4-mediated -hydroxylation of FFAs is markedly increased (Daly 2013

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Additionally, GLP-1R + neurons in the hindbrain locus coeruleus (LC) ( + DVC/AP neurons project to the lateral parabrachial nucleus (PBN), which is in close proximity to the LC