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Modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale, scored 02, 03, 01) (63, 64) for assessment of forelimb function impairment in rats that received cuprizone diet, and then cuprizone intragastrical applications, and thereby, cuprizone toxicity manifestations

22 Additionally, as mentioned earlier, the genes PINK1 and PRKN are key regulators of mitophagy and are commonly mutated in patients with PD

Both approaches work, as long as the 28-day window is respected

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