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Those who met the following criteria were excluded from the trial: estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m 2 , age of 30 years or younger, A1C less than 5.5% or greater than 11%, percutaneous coronary intervention within 15 days, coronary artery bypass graft for the qualifying event, or planned coronary revascularization procedure within 90 days after screening

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Finally, in week 8, after a 12-h fasting the participants underwent a new biochemical and anthropometric assessment

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But when care is designed around the patient, lower doses often prove sufficient