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Higher doses may be harder to find due to demand

Kleschyov et al., 2012

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

Diabetes Care 41 , 613619 (2018)

This is likely due to the fact that once the weight loss medication is stopped, patients do not feel satiated as quickly, frequent hunger returns, and previous food cravings come back