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It would take randomized, placebo-controlled trials in humans, ideally several, run in more than one country and by groups without a financial stake in the answer, measuring a pre-specified cognitive outcome rather than a grab-bag of secondary ones
The difference between both sides after treatment was highly significant ( P value = 0.03) (Table 2)
In some instances, upon administration (e.g., intratympanic injection) of a conventional otic formulation or composition (e.g., DSP in a buffer), the concentration of a drug in the perilymph of an individual will rise sharply (C max at about 1-2 hours) and then taper off to below C min
To achieve comparable results for a medium life span extension for D