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Research suggests that levels begin to drop as early as our late 20s or 30s

Li C, Li T, Tian X, An W, Wang Z, Han B, Tao H, Wang J, Wang X

By regulating the expression of the pro-invasive molecule alanyl aminopeptidase (Anpep) on the surface of endothelial cells, hepatic invariant-NKT (iNKT)-derived IL-22 modulated endothelial cell permeability and favored the seeding of circulating cancer cells in the liver, promoting CRC liver metastases (144)

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