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Cancellation, refills, and commitment questions Before subscribing, the practical questions matter: how refills are timed, what happens to an in-progress titration if you pause, and how cancellation works

Secondly, there was considerable variation in the risk of bias across the included studies, although exclusion of trials at high risk of bias in a sensitivity analysis did not alter the results of the main analysis

The reason SURMOUNT-5 matters so much is that it is not just another placebo-controlled success story