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In late 2024, the US Food and Drug Administration clarified its stance on several key compounds, moving them out of high-risk safety categories

GLP-1 therapy may help improve insulin sensitivity, reduce cravings, support fat loss, and improve energy levels

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In fact, lower IRRs were observed during both the initial (012 months) and late (1324 months) exposed periods compared with pretreatment, a pattern also seen for SGLT-2 and DPP-4 inhibitors, possibly reflecting increased healthcare contact or a healthier lifestyle during treatment