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All mice were male on a mixed background, were at least 8 weeks old and were individually housed and maintained on a 12 h lightdark cycle (lights off at 17:00 hours) at 25C and 5060% humidity with ad libitum access to water and standard chow diet

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Particle sizes were optimized, with some as low as 1103 nm and a uniformity (PDI) as tight as 0.084 in certain batches

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