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Notably, structure-based drug design targeting novel lactylation sitesparticularly when integrated with established immunotherapies such as checkpoint inhibitors (anti-PD-1/anti-CTLA-4 antibodies) and CAR-Tconstitutes a rationally prioritized therapeutic strategy to augment antitumor responses, representing a critical frontier warranting systematic interrogation

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That said, the homooligomeric ThDP-dependent enzymes participating in metabolism of glucose and amino acids, i.e., TKT, OGDH, DHTKD1, preserve their cluster partners in both of the studied experiments

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