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In our study, DPP-4 protein expression and enzymatic activity were significantly higher in OB+/DM+ compared with OB+/DM subjects, consistent with previous reports describing increased DPP-4 expression and activity in obesity and T2DM ( In the gastrointestinal system smooth muscle cells are exposed to excitatory and inhibitory effects of different peptides and neurotransmitters

Conclusion : Semaglutide, initially developed for the management of type 2 diabetes and obesity, offers a wide range of health benefits beyond its primary indications