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In the present study, a well established rat model of periodontitis was utilized, which involves a ligature around the cervix of the mandibular first molar tooth (9, 10)

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acts as a copper transporter and signaling modulator in research models Focus Areas: ECM signaling, oxidative stress responses, remodeling enzymes, and gene networks Proposed Mechanisms (Research Context) ECM Modulation: Influences genes tied to collagen, elastin, and glycosaminoglycan balance

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Endogenous DSIP has been detected in various brain regions, plasma, and peripheral tissues, though its concentrations are very low and its physiological fluctuations are not well-characterized