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The absence of glucose effects means dosing does not need to be coordinated with meals or adjusted for diabetic status, and there are no concerns about timing relative to insulin sensitivity

The MTHFR C677T polymorphism is common, affecting around 24% of the population overall, although prevalence varies considerably between ethnic groups

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H.ErlingeD.HustedS.KontnyF.et alPLATO Study Group (2010)