After 52 weeks, HbA1c was reduced by 0.4% (4 mmol/mol) by vildagliptin and 0.5% (5 mmol/mol) by glimepiride, body weight was slightly reduced by vildagliptin (0.2 kg) but increased by glimepiride (1.89 kg) and there was a 10-fold higher incidence of hypoglycemia in the glimepiride group
(1) By binding to GLP-1 receptors, Semaglutide: Enhances insulin secretion Suppresses glucagon release (which reduces blood sugar levels) Delays gastric emptying Promotes satiety These combined actions have been shown to help regulate blood sugar levels and reduce appetite
This glucose stabilization translates to fewer nocturnal hypoglycemic events and reduced cortisol spikes that would otherwise fragment sleep
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1 It is also indicated to reduce the risk of major adverse cardiovascular events (MACE) such as death, heart attack, or stroke in adults with overweight or obesity and established cardiovascular disease
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