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Detection of Markers in Serum and Tissue Biomarkers were assayed using commercially available kits in accordance with manufacturers guidelines, including fasted non-esterified FAs (NEFA) (Solarbio), lactate dehydrogenase (LDH) (Nanjing Jiancheng Bioengineering Institute, Nanjing, China), creatine kinase-MB (CK-MB) (Nanjing Jiancheng Bioengineering Institute), malondialdehyde (MDA) (Beyotime Institute of Biotechnology, Shanghai, China) and superoxide dismutase (SOD) (Beyotime Institute of Biotechnology)

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Another study, not yet published, is SURMOUNT-OSA, a clinical trial of 52-weeks that examined the efficacy and safety of TZP versus placebo in obese participants and an established OSA diagnosis for treatment of moderate and severe OSA (102)

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Its natural occurrence in the body also means established metabolic pathways for processing and elimination