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These therapeutic effects occur after the medication has entered systemic circulation , not during the absorption phase, which means that the presence or absence of food in the gastrointestinal tract at the time of injection is irrelevant to the drug's pharmacological activity

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Patients who maintain their topical protocol, follow sun protection guidance, and return for periodic maintenance sessions can keep melasma visibly controlled long-term

(3) optimizing glycemic control without excessive hypoglycemia ( These drugs have demonstrated significant multi-organ protective effects in sepsis models by modulating inflammation, oxidative stress, and tissue injury