omeprazole and b12 injections Vitamin B12 Injection at BiosenseClinic.com a Licensed Pharmacy Omeprazole and Vitamin B12 Deficiency

Vitamin B12 deficiency is a recognised nutritional complication following bariatric surgery, including gastric banding (laparoscopic adjustable gastric banding, LAGB)

Maintenance Phase: Once optimal B12 levels are achieved, the frequency of injections can be reduced

Once per week injections for 4-6 weeks, then monthly maintance

The use of H(2)-receptor antagonists and/or PPIs may impair the absorption of protein-bound dietary vitamin B12 and could contribute to the development of vitamin B12 deficiency with prolonged use.[189] The studies reviewed in this article clearly show that omeprazole therapy will decrease the absorption of vitamin B12 by preventing its cleavage from dietary proteins.[190] A number of studies have shown an association of decreased B12 absorption with prolonged PPI use.[189,190] However, PPIs have been shown to affect B12 absorption in very short periods of time as well.[191,192] One study showed a 72% decrease in B12 absorption on 20 mg of omeprazole (Prilosec) and an 88% decrease in B12 absorption on 40 mg of omeprazole after only 2 weeks of treatment

Source data are provided with this paper