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The two main root causes of SIBO are a sluggish migrating motor complex (MMC) and structural issues such as adhesions or ICV dysfunction

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As drug levels decline, appetite suppression weakens progressively

-arrestins were first recognized for desensitizing GPCRs by uncoupling them from G-proteins and promoting receptor internalization via clathrin-coated pits, but are now known to act as signaling scaffolds themselves, initiating distinct pathways like ERK, JNK, or NF-B activation