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The pro-depressant effects of MetSR may be mediated through chronic low-grade inflammation, as evidenced by recent research showing significant mediation (30.8% combined effect) through inflammatory markers including platelets, lymphocytes, neutrophils, C-reactive protein (CRP), leukocytes, and INFLA scores (Cen et al., 2024)

doi: 10.1172/JCI10842 114 da SilvaAAdo CarmoJMLiXWangZMoutonAJHallJE

Belli, Immediate or Delayed Dissection of Regional Nodes in Patients with Melanoma of the Trunk: A Randomised Trial, Lancet, Vol