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Some research suggests that vitamin C supplementation during pregnancy may help reduce the risk of adverse pregnancy outcomes and respiratory illness in children born to women who continue to smoke throughout pregnancy, despite receiving counseling to quit

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Lidocaine clearance has been used to assess liver transplant function, but its use is limited by the effect of hypoperfusion (as occurs in sepsis or volume depletion)

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This is usually a higher dose, sometimes given more frequently in order to encourage a rapid response to the biologic medicine