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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists
GIP receptors are expressed in developing tissues including the pancreas and cardiovascular system, adding theoretical considerations that have not been fully characterized in human development
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The STEP and SURMOUNT trial results demonstrated weight loss outcomes that diet programs simply cannot match, and that data has reached general audiences through media coverage and social proof
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