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[13] [25] Taken approximately 30 minutes after meals to coincide with the gastrocolic reflex [12] Stool softeners (e.g., docusate) should not be used for initial pharmacological treatment because their benefit has not been proven

Substantial weight loss may affect the hypothalamic-pituitary-ovarian axis, potentially leading to changes in menstrual regularity, particularly in women who experience rapid or significant weight reduction