Number of Treatments: One weekly injection initially, adjusted as needed
Krekels EH, Danhof M, Tibboel D et al , Ontogeny of hepatic glucuronidation
The retinal capillary damage central to DR leads to tissue hypoxia, altered venous oxygen saturation, and a compromised ability to regulate blood flow [87,88,89]
When cellular glutathione levels drop, the accumulation of unneutralized reactive oxygen species provokes mast cells to become hyper-reactive, inappropriately releasing massive quantities of histamine into the bloodstream
A similar biochemical mechanism occurring on metal thiolates would generate also metal sulphides, as demonstrated by mass spectrometric studies