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Mechanistically, they exert distinct SIRT1-dependent effects, such as Qufeng Epimedium Decoction stabilizing SIRT1 through CYLD-mediated deubiquitination and Wutou Decoction mediating HMGB1/NF-B deacetylation

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When ferritin is degraded, ROS accumulates and ferroptosis is subsequently triggered by the increase in the unstable iron content in cells [41]

It is important to note that a recent study revealed the opposite result with high doses of atorvastatin (40 m) in human cardiomyocytes and murine skeletal muscle cells, which is consistent with the adverse muscle effects of atorvastatin [229]