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It is administered as a once-daily subcutaneous injection, with dose titration to 3 mg

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doi:10.1016/j.biochi.2016.02.012 [PubMed] [Elsevier] Moll S, Varga EA

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Retatrutide users report similar fat intolerance but may also experience issues with very large meals of any composition, likely because the triple receptor activation provides more potent gastric slowing