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The androgen receptor sits in the dermal papilla, and dihydrotestosterone (DHT) binding there is a central driver of this miniaturization

Important Note on the Evidence Base Important note on the evidence base: Peer-reviewed BPC-157 research has been conducted predominantly in rodent models (Sprague-Dawley and Wistar rats), with a smaller body of in vitro work on isolated fibroblasts, endothelial cells, and tendon explants

The dose-response relationship in published cases strongly suggests that lower doses carry lower allodynia risk

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