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Starting too high causes : Severe nausea and vomiting Extreme fatigue Intolerable side effects Protocol abandonment Gradual titration : Minimizes side effects Allows adaptation Improves tolerance Maintains adherence Standard schedule : Start 2.5mg weekly, increase every 4 weeks until reaching maintenance dose

151,152 The airway of the newborn is affected by the amniotic fluid, placenta, and vagina during pregnancy and develops its microbiota as early as birth

MBS has emerged as a highly effective intervention, leading to remission of diabetes in approximately 31% to 56% of patients

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doi: 10.3390/genes12020222 44 KonishiAIdaSShojiYEtaniYKawaiM