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Others experience more modest changes

The significance of this weak binding to IGFBPs is that the compound can exert more pharmacological action in animal subjects since IGFBPs decrease the pharmacological activity of hormones that are strongly bound to it

Free Radic Biol Medic 122:420 Ding L, Charles MT, Carissea O, Tsao R, Dube C, Khanizadeh S (2011) Changes in ascorbateglutathione pathway enzymes in response to Mycosphaerella fragariae infection in selected strawberry genotypes

2g), which was associated with increased caspase-3 activation (Fig