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We know that cholesterol induces the hormone synthesis such as cortisol, the aldosteron, the testosteron and the oestrogens which are the sex hormones may be the increasing in cholesterol in the HCD rats would have contributed to increase the rate of these hormones and induce significantly increasing of body weight in rat fed with HCD (Fidele, Barama, Talla, & Dimo, 2017)

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- Use lithium as the basic treatment, specifically for bipolar disorder type 1, and combine with: - Quetiapine (best evidence), depending on the patients risk of cardiovascular disease and metabolic risk profile, use the following alternatives: lurasidone, cariprazine - Lamotrigine may be considered when lithium or antipsychotics are unsuitable