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For example, ALS presents both sporadic and familial forms, often linked to defective DNA repair, which leads to neuronal damage, premature aging, and subsequent neurodegeneration ( 2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation ( Figure 1

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Tesamorelin works by stimulating the pituitary gland to increase the natural production of HGH (Human Growth Hormone)

HDACis are in early stage clinical trials for Niemann-Pick type C1 (NCT02124083 i ), Alzheimers (NCT03056495 i ), epilepsy (NCT03894826 i ), and Crohns disease (NCT03167437 i ) [90], with Depakene (valproic acid) being used as a first-line therapy for migraine prophylaxis and found to be well-tolerated [91,92]

However, those with active cancer are generally advised to avoid these compounds [4, 5]