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The methylation status of the tRNA Sec is dependent on selenium status, and the presence of the ribosyl methylation regulates the efficient translation of a subset of selenoprotein transcripts, including GPx1

Nevertheless, several cellular studies have suggested the protective roles of chemical anti-oxidants, such as GSH, as well as drug metabolizing enzymes, such as NQO1 and UDP-glucuronosyltransferases (UGTs), against AQ-induced cytotoxicity (Tafazoli and OBrien, 2009

Cureus 16 (7), e64629 (2024)