allodynia from semaglutide A real‐world disproportionality analysis of semaglutide: Post‐marketing pharmacovigilance data Adverse events in different Semaglutide ameliorates osteoarthritis progression through

Nutrients/DNA SNP genomics 2

In terms of oral options, a recent study presented at the 2023 American Diabetes Association Sessions found that higher doses of oral semaglutide (currently available in low doses as Rybelsus) were as effective in weight loss as the injectable formulation

What the evidence suggests (as of 2025) No strong link between GLP-1 therapy and direct dental harm (decay, periodontitis, enamel loss)

This can be problematic for people with certain health conditions or older adults whose digestive efficiency may be compromised

Table 1: Adverse Reactions Occurring 5% in Pooled Clinical Studies up to 28 Weeks Duration in Adults with Type 1 Diabetes Table 2: Adverse Reactions Occurring 5% in Pooled Clinical Studies up to 1 Year Duration in Adults with Type 2 Diabetes Table 3: Adverse Reactions Occurring 10% in a 5-Year Study of Adults with Type 2 Diabetes Table 4: Adverse Reactions Occurring 5% in a 28-Week Clinical Study in Pediatric Patients with Type 1 Diabetes Severe Hypoglycemia Hypoglycemia was the most commonly observed adverse reaction in patients treated with insulin glargine