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What Affects Stack Results Body Composition Through the Timeline Retatrutide's glucagon-receptor activation is mechanistically associated with somewhat better lean-mass preservation than pure GLP-1 agonists, but lean-mass loss during aggressive deficit remains a known issue across the GLP-1 class
However, this practice remains controversial , as its actual benefits are still under debate and the associated risks are not negligible
PubMed pubmed.ncbi.nlm.nih.gov [87] Efficacy and safety of GLP-1RAs for people with obesity: A systematic review based on RCT and Bayesian network meta-analysis ScienceDirect [88] GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review ScienceDirect
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