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www.jdmoyer.com/2011/09/03/b-vitamins-mood-and-methylation-its-complicated/ Lynch, B., ND

Studies on Tnf knockout mice or mice lacking TNF- receptors have produced mixed results, probably because other mechanisms compensate for the loss of TNF, since blocking only one cytokine may not be sufficient to prevent DA neuronal death caused by inflammation

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Hence, the microclots may result in decreased circulation and blockage of the microcapillaries, resulting in ischemia and therefore many symptoms of ME/CFS, as seen in Figure 9