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Dulaglutide also has shown kidney benefits (slower progression of albuminuria) in that trial

The majority of sitagliptin (79%) is excreted unchanged in the urine

Incretins also act on appetite-regulating centres in the brain, particularly the hypothalamus, where they promote feelings of satiety and reduce hunger signals

Research instead highlights how it improves metabolic health, which can lessen long-term vascular harm, including harm to the eyes

There is some evidence that L-carnitine may help preserve lean muscle mass during calorie restriction, though the data is mixed and the effect sizes are small