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Keywords: autoimmune thyroid disease, glp-1 receptor agonists, graves disease, hashimoto thyroiditis, immunometabolism, obesity, semaglutide, thyroid autoimmunity, tirzepatide Introduction and background Introduction Autoimmune thyroid disease (AITD), encompassing Hashimoto thyroiditis and Graves disease, is the most common organ-specific autoimmune disorder, affecting up to 5% of the general population, with a marked female predominance of nearly 5:1 compared with men [1,2]