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The most strongly correlated risk factors include 4,24 : Hearing loss

Glutathione extraction from S

Glutathione (GSH) which prevents skin pigmentation by producing Pheo Melanin which makes skin Whiter

The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations