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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for several indications: type 2 diabetes management (under the brand names Ozempic and Rybelsus), chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity (under the brand name Wegovy), and in adolescents aged 12 years and older with obesity

The gradual dose titration recommended in prescribing guidance aims to minimise gastrointestinal side effects by allowing the body time to adapt to the medication's effects on gut motility

Matching limited the risk of bias, and subsequent adjustment for baseline characteristics was also carried out to reduce the chance of confounding

If your doctor prescribes Ozempic for weight loss, that's considered "off-label" because that's outside of the FDA's approval, so your insurance usually won't cover it

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