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Mitchell et al.[6] measured the level of GSH depletion in the liver (of mice), and the amount of covalent binding of radiolabeled APAP metabolites (later identified as NAPQI) in the liver after a wide range of doses of APAP

Suppression of oxidant-induced glutathione synthesis by erythromycin in human bronchial epithelial cells

The oxidation steps, utilizing glucose-6-phosphate (G6P) as the substrate, occur at the beginning of the pathway and generate 2 moles of NADPH

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