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Ethanol-induced iron overload and the underlying mechanisms Iron overload in ALD It has been well demonstrated that ethanol exposure could induce iron overload in human beings and laboratory animals evidenced by the increase of serum/hepatic iron levels, serum ferritin level, and transferrin saturation (TS) [18, 70, 71]

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Iron overload in the liver is a hallmark of ALD, which may have both diagnostic and prognostic value for ALD [19, 20]