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Since the inaugural successful cryopreservation of a human oocyte in 1986, technological advancements have provided women with a form of fertility insurance. Nevertheless, oxidative stress exerts a profound influence on oocyte quality and the outcomes of cryopreservation

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Thus, in the lumen of the ER, there is a substantially higher concentration of GSSG, as compared with the rest of the cell which allows the formation of native protein disulfide bonds and also the isomerization of non-native disulfide bonds