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& Merrill, J

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This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature

An apical diastolic murmur may be heard due to increased flow through the mitral valve (relative mitral stenosis)

Decisions should be individualized based on the patients overall risk profile, benefits of therapy, and clinical judgment