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3-AR knockout mice: In 3-AR gene knockout mice, the lipolysis effect of AOD 9604 was significantly weakened, confirming that its effect depends on the 3-AR signaling pathway

Chondrocytes expanded to population doubling level 9 (PDL9) were treated with FOXO4-DRI to remove accumulated senescent cells

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Withdrawal responses were measured using von Frey filaments at 0, 2, 6 h and 4, 7 d after incision