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Some patients with mild cognitive impairment, age-related memory decline, and early-stage dementia have demonstrated improvements in memory, attention, and daily functioning in controlled studies

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Indeed, Pink1-KO mice, a model that is typically asymptomatic of PD and void of dopaminergic degeneration, exhibited a pronounced reduction in the density of tyrosine hydroxylase-positive neurons in the dorsal and ventral striatum and dopamine transporters following infection by a pathogenic Gram-negative bacterium, Citrobacter rodentium (Matheoud et al., 2019)

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Modulation of Inflammatory Pathways Persistent tendon pain is not always driven by inflammation alone, but inflammatory signaling can still play an important role, especially in the early stages of injury

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